HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Alcohol → 3-(Benzyloxy)-5-bromopyrazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Amino-3,5-dibromopyrazine | HCID 620004 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(Benzyloxy)-5-bromopyrazin-2-amine | HCID 10755162 | — |
Reaction Steps
NaH, 60% in oil (36.98 mg, 0.9247 mmol) was added to a solution of phenylmethanol (100 mg, 0.9247 mmol) in THF (5 mL). The mixture was stirred at ambient temperature for 20 minutes and then 3,5-dibromopyrazin-2-amine (116.9 mg, 0.4624 mmol) was added and the reaction mixture heated under microwave conditions for 20 minutes at 80° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062008B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-f75c81a92d4e40a2862f900d1aafafa8 |
| Source note | uspto-grants-2015_06 |