HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Chloro-5-(methylsulphonyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Thiosulfate | HCID 24477 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Chloro-5-(methylsulfanyl)benzoic acid | HCID 608814 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Solvent | Ethylenediaminetetraacetic Acid | HCID 6049 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-Chloro-5-(methylsulphonyl)benzoic acid | HCID 2329132 | — |
Reaction Steps
To a solution of 2-chloro-5-(methylthio)benzoic acid (6.05 g, 30 mmol) and NaHCO3 (20 g, 240 mmol) in NaOH 0.5N (75 ml) a solution of oxone (24 g) in EDTA (0.0004M, 90 ml) was added. After 1 hour at RT Na2S2O3 (15 g in 100 ml of water) was added; after 10 min HCl 4N was added to pH 2. The white solid was filtered, washed with water and dried in vacuum at 70° C. Yield 6 g white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062033B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-1af98a6918ec49cb861a10248b48a5e4 |
| Source note | uspto-grants-2015_06 |