反应详情

2-chloro-5-(methylsulfonyl)benzoic acid (4 g, 0.016 mol) was dissolved in MeOH (10 ml) and thionyl chloride (1 ml) was added. The reaction was stirred for 72 h at RT. Solvents were evaporated and crude solid was dissolved in DCM and washed with saturated aqueous solution of NaHCO3. The organic solvent was dried (Na2SO4) and evaporated to obtain 0.88 g of the title compound as white solid.

1. customSolvents were evaporated
2. dissolutioncrude solid was dissolved in DCM
3. washwashed with saturated aqueous solution of NaHCO3
4. dry with materialThe organic solvent was dried (Na2SO4)
5. customevaporated