反应详情

To a solution of pyridine-2,3-dicarboxylic acid (50.0 g, 0.299 mol) in methanol (500 ml) was added con. sulfuric acid (20 ml). After heated to reflux for 24 hours, the mixture was basified with saturate sodium carbonate solution until pH=8 and then extracted with ethyl acetate. The combined extracts were washed with brine, dried over magnesium sulphate, filtered and evaporated to give D78 (45.7 g) as a white solid.

1. temperatureAfter heated
2. temperatureto reflux for 24 hours
3. extractionextracted with ethyl acetate
4. washThe combined extracts were washed with brine
5. dry with materialdried over magnesium sulphate
6. filtrationfiltered
7. customevaporated
8. customto give D78 (45.7 g) as a white solid