N-(5-Chlorothiophene-2-carbonyl)-2-methylalanine → HCID 45123180, compound

HRID 2174702Notes

Reaction equation

HRID 2174702 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]([CH3:15])([CH3:14])[C:11]([OH:13])=[O:12])=O)=[CH:4][CH:3]=1>C(OC(=O)C)(=O)C>[Cl:1][C:2]1[S:6][C:5]([C:7]2[O:12][C:11](=[O:13])[C:10]([CH3:15])([CH3:14])[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 61263022N-(5-Chlorothiophene-2-carbonyl)-2-methylalanine

Product 1

HCID 45123180HCID 45123180, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

1.0 g (4.0 mmol) 2-[(5-chloro-thiophen-2-yl)-carbonylamino]-2-methyl-propionic acid in 30 ml acetic anhydride are stirred for 1 h at 85° C. Then the reaction mixture is evaporated to dryness.

Workup

  1. customThen the reaction mixture is evaporated to dryness

Sources & evidence

ORD record
ord-47d3523f15eb4e5d9634c521fc5bcd68
Source dataset
uspto-grants-2015_06
Patent number
US09062034B2

Reaction notes

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