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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2174705Generated: October 29, 2026

N-(5-Ethynylthiophene-2-carbonyl)-2-methylalanine → 2-(5-Ethynylthiophen-2-yl)-4,4-dimethyl-1,3-oxazol-5(4H)-one

https://huagongshe.com/reaction/2174705

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(5-Ethynylthiophene-2-carbonyl)-2-methylalanineHCID 45122350—
SolventAcetic AnhydrideHCID 7918—
Product2-(5-Ethynylthiophen-2-yl)-4,4-dimethyl-1,3-oxazol-5(4H)-oneHCID 71425647—

Reaction Steps

Prepared analogously to Example 3-a from 2-[(5-ethynyl-thiophen-2-yl)-carbonylamino]-2-methyl-propionic acid in acetic anhydride at 65° C. with subsequent purification by chromatography on silica gel with the eluant (petroleum ether/ethyl acetate=2:1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09062034B2
Source datasetuspto-grants-2015_06
ORD IDord-3b1036922e4b4333aa2ddb0389686b95
Source noteuspto-grants-2015_06