5-Chlorothiophene-2-carbonyl Chloride → HCID 68486309, compound

Participants

Reaction Steps

1.14 g (6.16 mmol) 2-amino-3-methoxy-2-methoxymethyl-propan-1-ol are suspended in 9 ml THF, cooled in the ice bath and combined with 2.56 ml (18.4 mmol) TEA. 1.12 g (6.19 mmol) 5-chlorothiophene-2-carboxylic acid chloride are dissolved in 6 ml THF and added dropwise. After 1.5 h the mixture is filtered and the filtrate is concentrated by evaporation i.vac. Then it is purified by chromatography through RP material (Microsorb C18 Varian; eluant:water/acetonitrile/trifluoroacetic acid=90:10:0.1=>0:100:0.1).

Provenance & Evidence