HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2174715Generated: November 1, 2026
2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline → HCID 59452288, compound
https://huagongshe.com/reaction/2174715
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| Reactant | HCID 21822925 | HCID 21822925 | — |
| Reactant | N-(5-Chlorothiophene-2-carbonyl)-2-(methoxymethyl)-O-methylserine | HCID 67456065 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59452288 | HCID 59452288 | — |
Reaction Steps
0.05 g (0.16 mmol) 2-[(5-chloro-thiophene-2-carbonyl)-amino]-3-methoxy-2-methoxymethyl-propionic acid are dissolved in 1.5 ml THF and at room temperature 0.04 g (0.16 mmol) 2-ethoxy-1-ethoxycarbonyl-1.2-dihydroquinoline (EEDQ) are added. After 30 min, 0.029 g (0.16 mmol) of 3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine is added and the mixture is stirred for 12 h at 40° C. Then it is concentrated by evaporation i.vac. And purified by chromatography through RP material (Microsorb C18 Varian; eluant: water/acetonitrile/trifluoroacetic acid=90:10:0.1=>0:100:0.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09062034B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-b9807cb7f4374c5ba6eb6d040cf90024 |
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| Source note | uspto-grants-2015_06 |
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