Methyl Acrylate → HCID 86644561, compound

Participants

Reaction Steps

A mixture of 120 mg (0.226 mmol) tert.butyl(R)—N-[2-(prop-2-enyloxy)-1-methyl-1-(3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylcarbamoyl)ethyl]-carbamate (prepared from (R)—O-allyl-α-methyl-N-butoxycarbonylserine and 3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine) in methylene chloride is rinsed for 30 min with argon, combined with 0.42 ml (4.66 mmol) methyl acrylate and 2nd generation Grubbs catalyst and heated to boiling for 4 h. Then the mixture is concentrated by evaporation and purified by chromatography.

Provenance & Evidence