Potassium bisulfate → HCID 68485592, compound

HRID 2174722Notes

Reaction equation

HRID 2174722 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2([C:16]([O:18][CH3:19])=[O:17])[CH2:14][CH:13]3[O:15][CH:12]3[CH2:11]2)=[O:8])=[CH:4][CH:3]=1.S([O-])(O)(=O)=[O:21].[K+]>C(O)(=O)C>[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2([C:16]([O:18][CH3:19])=[O:17])[CH2:14][CH:13]([OH:21])[CH:12]([OH:15])[CH2:11]2)=[O:8])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 516920Potassium bisulfateHCID 86644563HCID 86644563, compound

Product 1

HCID 68485592HCID 68485592, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
40 °C

Procedure

A mixture of 0.76 g (1.84 mmol) methyl 1-[(5-chloro-thiophen-2-yl)-carbonylamino]-3,4-epoxy-cyclopentane-1-carboxylate, 3.0 ml acetic acid and 0.38 g potassium hydrogen sulphate are stirred for 4 h at 40° C. Then the mixture is concentrated by evaporation, dissolved in DMF, acidified with trifluoroacetic acid and purified by preparative HPLC.

Workup

  1. concentrationThen the mixture is concentrated by evaporation
  2. dissolutiondissolved in DMF
  3. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-ed86165850fd4446ab69bdb2f6aca4f9
Source dataset
uspto-grants-2015_06
Patent number
US09062034B2

Reaction notes

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