HCID 71561665, compound → CDKI-73

HRID 2174726Notes

Reaction equation

HRID 2174726 reaction equation
CN(C)/[CH:3]=[C:4](\[F:15])/[C:5]([C:7]1[S:11][C:10]([NH:12][CH3:13])=[N:9][C:8]=1[CH3:14])=O.[NH:17]([C:21]1[CH:22]=[C:23]([S:27]([NH2:30])(=[O:29])=[O:28])[CH:24]=[CH:25][CH:26]=1)[C:18]([NH2:20])=[NH:19]>O(CCO)C>[F:15][C:4]1[C:5]([C:7]2[S:11][C:10]([NH:12][CH3:13])=[N:9][C:8]=2[CH3:14])=[N:19][C:18]([NH:17][C:21]2[CH:22]=[C:23]([S:27]([NH2:30])(=[O:28])=[O:29])[CH:24]=[CH:25][CH:26]=2)=[N:20][CH:3]=1

Participants

4

Reactant 2

HCID 71561665HCID 71561665, compoundHCID 178512551HCID 178512551, compound

Product 1

HCID 71561915CDKI-73

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of (Z)-3-(dimethylamino)-2-fluoro-1-(4-methyl-2-(methylamino)thiazol-5-yl)prop-2-en-1-one (1 mmol) and 3-guanidinobenzenesulfonamide (2 mmol) in 2.5 mL 2-methoxylethanol was heated at 140° C. for 45 minutes under microwave radiation. The mixture was purified by column chromatography using EtOAc/PE or EtOAc/MeOH to yield the titled compound as yellow solid.

Workup

  1. customThe mixture was purified by column chromatography

Sources & evidence

ORD record
ord-2f9383af6c544e798469a2c9d15ca580
Source dataset
uspto-grants-2015_06
Patent number
US09062039B2

Reaction notes

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