Lithium Chloride → HCID 66750081, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Ethyl 5-(4-chlorobenzyl)-2-iodo-1,3-oxazole-4-carboxylate (261 mg, 0.666 mmol), Tetrakis(triphenylphosphine)palladium(0) (38.5 mg, 0.0333 mmol), Copper(I) iodide (38.1 mg, 0.200 mmol) and Lithium chloride (84.8 mg, 2.00 mmol) under atmosphere of argon was dissolved in 1,4-Dioxane (18 mL) and Trimethyl(4-pyridyl)tin (207 uL, 1.20 mmol) was added. The mixture was heated at 100° C. for 2 h. The mixture was evaporated and the residue was purified by chromatography to afford Ethyl 5-(4-chlorobenzyl)-2-pyridin-4-yl-1,3-oxazole-4-carboxylate (0.133 g, 58.2%). LCMS (FA) ES+ 343.2, 345.1

Provenance & Evidence