Acetic Anhydride → HCID 89601742, compound

HRID 2174932Notes

Reaction equation

HRID 2174932 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[C:3]=1[CH2:10][CH3:11].[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:14])[CH3:13])=[C:4]([CH3:9])[C:3]=1[CH2:10][CH3:11]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 89601951HCID 89601951, compound

Product 1

HCID 89601742HCID 89601742, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 3.86 g of the bromide prepared in Example 212a in 48 ml pyridine, 2.04 ml of acetic anhydride was added dropwise at 0° C. and stirred for 20 hours at 25° C. The reaction mixture was concentrated in vacuo and the crude product thus obtained was purified by column chromatography on silica gel with hexane/0-100% ethyl acetate. In this manner, 3.73 g of the title compound was obtained.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe crude product thus obtained
  3. customwas purified by column chromatography on silica gel with hexane/0-100% ethyl acetate

Sources & evidence

ORD record
ord-a79f1eaec4d94a30af26a4e123ca880c
Source dataset
uspto-grants-2015_06
Patent number
US09062041B2

Reaction notes

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