Methyl iodide → HCID 87097575, compound

Participants

Reaction Steps

To the stirred solution of Example 6 (0.014 mmol) in dry THF was added potassium-t-butoxide (0.157 mmol) at 0° C. Reaction mixture was stirred further for 15 minutes, followed by addition of methyl iodide (0.125 mmol). Reaction mixture was warmed to RT and stirred overnight. Solvent was removed and diluted with EtOAc. Organic layer was washed with water, dried over anhydrous Na2SO4 and solvent was removed. Crude product was further purified (silica gel column, MeOH/CHCl3 as eluent) to obtain the title compound. 1H NMR (300 MHz, DMSO-d6): δ 9.19 (s, 1H), 8.16-8.11 (m, 2H), 8.00-7.91 (m, 1H), 7.89 (s, 3H), 7.76 (brs, 1H), 6.87 (d, J=1.8 Hz, 1H), 6.79 (q, J=4.5 Hz, 1H), 3.92 (s, 3H), 2.89 (d, J=4.2 Hz, 3H), 1.82 (s, 6H); MS (m/z): 541(M+1)+.

Provenance & Evidence