Trifluoroacetic acid → HCID 67086992, compound

Participants

Reaction Steps

To 1S,6R)-tert-butyl 8-(6-methyl-2-(1H-1,2,3-triazol-1-yl)nicotinoyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate (1.05 g, 2.64 mmol) in DCM (15 mL) was added TFA (3 mL). The resulting mixture was allowed to stir at ambient temperature. After 16 h the mixture was concentrated under reduced pressure and the crude residue was purified by FCC (SiO2, gradient DCM to 15% MeOH/10% NH3/DCM) to yield the title compound (790 mg, 71%). MS (ESI) mass calcd. for C15H18N6O, 298.2; m/z found, 299.1 [M+H]+.

Provenance & Evidence