反应详情

温度

50 °C

To 2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid (406 mg, 1.5 mmol) in PhCH3 (5 mL) was added SOCl2 (117 μL, 1.6 mmol). The flask was heated with an oil bath to 50° C. for 1 h. To (1S,6R)-tert-butyl 3,8-diazabicyclo[4.2.0]octane-3-carboxylate (260 mg, 1.3 mmol) and Na2CO3 (519 mg, 4.9 mmol) in PhCH3 (5 mL) and H2O (5 mL) at 0° C. was added the above solution dropwise. The reaction was allowed to warm slowly to rt and stir for 15 h and extracted with DCM (2×). The combined organics were dried (Na2SO4). Purification via silica gel chromatography (1-7% 2M NH3/MeOH in CH2Cl2) gave 335 mg (68%) of the title compound. MS (ESI) mass calcd. C20H24FN5O3, 401.44; m/z found 346.1 [M−C(CH3)3]+.

1. temperatureto warm slowly to rt
2. extractionextracted with DCM (2×)
3. dry with materialThe combined organics were dried (Na2SO4)
4. customPurification via silica gel chromatography (1-7% 2M NH3/MeOH in CH2Cl2)