反应详情

To 3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid (390 mg, 1.9 mmol) in CH2Cl2 (18 mL) at 0° C. was added DMF (15 μL, 0.2 mmol) and oxalyl chloride (190 μL, 2.3 mmol). After 20 min, the 0° C. ice bath was removed and the reaction allowed to warm to rt. After 30 min the mixture was concentrated, diluted with CH2Cl2 (9 mL) and added to (1S,6R)-tert-butyl 3,8-diazabicyclo[4.2.0]octane-3-carboxylate (260 mg, 1.3 mmol) in CH2Cl2 (9 mL) and TEA (390 μL, 2.9 mmol). After judged complete by TLC and LC-MS, the reaction was diluted further with CH2Cl2 and washed with 1 N KHSO4. The aqueous layer was with CH2Cl2. The combined organics were dried (Na2SO4) to give a yellow foam. Purification via silica gel using 40-100% EtOAc in hexanes gave 656 mg (86%) of the title compound as a colorless oil. MS (ESI) mass calcd. C20H24FN5O3, 401.44; m/z found 346.0 [M−C(CH3)3]+.

1. customthe 0° C. ice bath was removed
2. concentrationAfter 30 min the mixture was concentrated
3. additiondiluted with CH2Cl2 (9 mL)
4. washwashed with 1 N KHSO4
5. dry with materialThe combined organics were dried (Na2SO4)
6. customto give a yellow foam
7. customPurification via silica gel using 40-100% EtOAc in hexanes