反应详情

To (1S,6R)-tert-butyl 8-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate (656 mg, 1.6 mmol) in CH2Cl2 (10 mL) was added TFA (10 mL). After 3 h, the volatiles were removed via rotovap. The resulting residue was neutralized using 5% Na2CO3 (aq) and extracted with CH2Cl2 (3×). The aqueous layer was saturated with NaCl and extracted with CH2Cl2 (3×). The combined organics were dried (Na2SO4) and concentrated to give the title compound as a yellow foam that was used without further purification. MS (ESI) mass calcd. C15H16FN5O, 301.32; m/z found 302.0 [M+H]+.

1. customthe volatiles were removed via rotovap
2. extractionextracted with CH2Cl2 (3×)
3. extractionextracted with CH2Cl2 (3×)
4. dry with materialThe combined organics were dried (Na2SO4)
5. concentrationconcentrated