HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloro-5-fluoropyrimidine → 2-Chloro-4,5-dimethylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Reactant | 2-Chloro-5-fluoro-4-methylpyrimidine | HCID 20778073 | — |
| Product | 2-Chloro-4,5-dimethylpyrimidine | HCID 12581784 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 32, substituting 2,4-dichloro-5-methylpyrimidine for 2,4-dichloro-5-fluoropyrimidine. MS (ESI): mass calculated for C6H7ClN2, 142.03, m/z found 143.1 [M+1]+. 1H NMR (500 MHz, CDCl3): 8.32-8.25 (m, 1H), 2.52-2.46 (m, 3H), 2.28-2.22 (m, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062044B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-1989a621b8074b8caa040bbfb8e840a1 |
| Source note | uspto-grants-2015_06 |