2-Chloro-6-methylnicotinic acid → 3-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acid

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Reaction Steps

The title compound was prepared in a manner analogous to Intermediate 46 substituting 3-bromo-2-pyridinecarboxylic acid for 2-chloro-6-methylnicotinic acid. MS (ESI): mass calculated for C8H6N4O2, 190.10; m/z found 191.1 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.77 (d, J=4.3 Hz, 1H), 8.26 (dt, J=6.5, 3.3 Hz, 1H), 7.88 (s, 2H), 7.65 (dd, J=8.2, 4.7 Hz, 1H).

Provenance & Evidence