2-Chlorobenzoxazole → HCID 52915314, compound

Participants

Reaction Steps

The title compound was prepared in a manner analogous to Example 1, substituting the trifluoro acetic acid salt of (3,8-diaza-bicyclo[4.2.0]oct-8-yl)-(2,6-dimethoxy-phenyl)-methanone (Intermediate 4) for biphenyl-2-yl-(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone and 2-chlorobenzoxazole for 2-chloro quinoxaline. MS (ESI) mass calcd. for C22H23N3O3, 393.45; m/z found, 394.0 [M+H]+. 1H NMR (CDCl3): 7.54-7.26 (m, 3H), 7.24-7.10 (m, 2H), 7.08-7.02 (m, 0.6H), 6.80-6.73 (m, 0.4H), 6.33-6.22 (m, 1H), 4.74-4.64 (m, 1H), 4.14-3.56 (m, 5H), 3.50-3.35 (m, 1H), 2.99-2.85 (m, 1H), 2.72-2.56 (m, 1H), 2.36-2.20 (m, 5H), 2.03-1.78 (m, 2H).

Provenance & Evidence