2-Chloroquinoxaline → HCID 52915315, compound

Participants

Reaction Steps

The title compound was prepared in a manner analogous to Example 1, substituting substituting the trifluoro acetic acid salt of (3,8-diaza-bicyclo[4.2.0]oct-8-yl)-(2,6-dimethoxy-phenyl)-methanone (Intermediate 4) for biphenyl-2-yl-(3,8-diaza-bicyclo[4.2.0]oct-8-yl)-methanone and 2-chloro phenyl pyrimidine for 2-chloro quinoxaline. MS (ESI) mass calcd. for C25H26N4O3, 430.20; m/z found, 431.3 [M+H]+. 1H NMR (CDCl3): 8.64 (d, J=5.3, 0.75H), 8.42 (d, J=5.2, 0.25H), 8.11-8.00 (m, 2H), 7.65 (d, J=5.3, 0.75H), 7.58-7.37 (m, 4H), 7.23-7.11 (m, 0.75H), 6.95 (d, J=5.2, 0.75H), 6.54 (d, J=8.4, 0.75H), 5.33-4.76 (m, 0.5H), 4.60-4.20 (m, 1.5H), 4.09-3.04 (m, 9H), 3.00-2.72 (m, 1H), 2.25-1.80 (m, 2H), 1.75-1.60 (m, 2H).

Provenance & Evidence