2-Chloro-4,6-dimethylpyrimidine → HCID 67086946, compound

Participants

Reaction Steps

The title compound was prepared in a manner analogous to Example 1, substituting (1R,6S) (3,8-diaza-bicyclo[4.2.0]oct-8-yl)-(2-thiophen-2-yl-phenyl)-methanone (Intermediate 7) for biphenyl-2-yl-(3,8-diaza-bicyclo[4.2.0]oct-8-yl)-methanone and 2-chloro-4,6-dimethyl-pyrimidine for 2-chloro quinoxaline. MS (ESI) mass calcd. for C23H24N4OS, 404.53; m/z found 405.2 [M+H]+. 1H NMR (CDCl3) 7.54-7.27 (m, 4H), 7.25-7.12 (m, 2H), 7.07 (dd, J=5.1, 3.6, 0.7H), 6.81-6.75 (m, 0.3H), 6.29 (d, J=17.6, 1H), 4.78-4.54 (m, 0.75H), 4.10-3.55 (m, 4.5H), 3.52-3.33 (m, 0.75H), 3.01-2.90 (m, 0.6H), 2.73-2.56 (m, 1H), 2.30 (d, J=23.8, 6H), 2.10-1.50 (m, 2.4H).

Provenance & Evidence