2-Chloro-4,6-dimethylpyrimidine → HCID 52915432, compound

HRID 2175040Notes

Reaction equation

HRID 2175040 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([N:9]2[CH2:15][CH:14]3[CH:11]([CH2:12][NH:13]3)[CH2:10]2)[N:3]=1.[C:16]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22](N1C2C(CCNC2)C1)=[O:23].ClC1N=C(C)C=C(C)N=1.ClC1C=NC2C(=CC=CC=2)N=1>>[C:16]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]([N:13]1[CH2:12][CH:11]2[CH:14]1[CH2:15][N:9]([C:4]1[N:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[N:3]=1)[CH2:10]2)=[O:23]

Participants

5

Reactant 4

HCID 205502-Chloro-4,6-dimethylpyrimidineHCID 2389382-ChloroquinoxalineHCID 67086667HCID 67086667, compoundHCID 67086871HCID 67086871, compound

Product 1

HCID 52915432HCID 52915432, compound

Procedure

The title compound was prepared from Intermediate 9 in a manner analogous to Example 1, substituting biphenyl-2-yl-(3,6-diaza-bicyclo[3.2.0]hept-6-yl)-methanone for biphenyl-2-yl-(3,8-diaza-bicyclo[4.2.0]oct-8-yl)-methanone and 2-chloro-4,6-dimethyl-pyrimidine for 2-chloro quinoxaline. MS (ESI) mass calcd. for C24H24N4O, 384.49; m/z found, 385.2 [M+H]+.

Sources & evidence

ORD record
ord-9e271b29e2eb42bd8d6a63cb69705965
Source dataset
uspto-grants-2015_06
Patent number
US09062044B2

Reaction notes

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