HuagongsheHuagongshe Chemistry Print Report · For research reference only
cis-3-Boc-3,8-diazabicyclo[4.2.0]octane → (1S,6R)-3-(4,6-Dimethylpyrimidin-2-yl)-8-{[2-fluoro-6-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-3,8-diazabicyclo[4.2.0]octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | cis-3-Boc-3,8-diazabicyclo[4.2.0]octane | HCID 16099092 | — |
| Reactant | 2-(3-Methyl-1,2,4-oxadiazol-5-yl)benzoic acid | HCID 23146305 | — |
| Reactant | (1S,6R)-3,8-Diazabicyclo[4.2.0]octan-8-yl(2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methanone | HCID 67086669 | — |
| Reactant | 2-Fluoro-6-(3-methyl-1,2,4-oxadiazol-5-yl)benzoic acid | HCID 67086832 | — |
| Product | (1S,6R)-3-(4,6-Dimethylpyrimidin-2-yl)-8-{[2-fluoro-6-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-3,8-diazabicyclo[4.2.0]octane | HCID 67086602 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 12, Step B substituting Intermediate 34 for (1R,6S) 3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester and Intermediate 16 for 2-(3-methyl-1,2,4-oxadiazol-5-yl)benzoic acid. MS (ESI) mass calculated for C22H23FN6O2, 422.19; m/z found, 423.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062044B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-279fa587ab00452c97ba056867be34ab |
| Source note | uspto-grants-2015_06 |