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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2175063Generated: October 31, 2026

4,4,5,5-Tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane → 4-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/2175063

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,4,5,5-Tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolaneHCID 11243929—
Reactanttert-Butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylateHCID 46738270—
Product4-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl esterHCID 67248680—

Reaction Steps

The preparation is carried out analogously to FS 103 starting from 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (preparation analogous to US 2005/176722) and 4,4,5,5-tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09062015B2
Source datasetuspto-grants-2015_06
ORD IDord-4ca2c8e74a624908b27798dad5c86c15
Source noteuspto-grants-2015_06