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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2175066Generated: November 1, 2026

4-Boc-1-(6-bromo-2-pyridyl)piperazine → 4-[6-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/2175066

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Boc-1-(6-bromo-2-pyridyl)piperazineHCID 16059046—
Reactant2-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 53250114—
Product4-[6-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl esterHCID 67247582—

Reaction Steps

The preparation is carried out analogously to FS 102 starting from 4-(6-bromopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (US 2005/176722) and 2-(8,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09062015B2
Source datasetuspto-grants-2015_06
ORD IDord-853ece7f9c2943929df6907fccc71933
Source noteuspto-grants-2015_06