4-Boc-1-(6-bromo-2-pyridyl)piperazine → 4-[6-(1,1,3,3-Tetramethylindan-5-yl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16](Br)[N:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CC1(C)C(C)(C)OB([C:29]2[CH:30]=[C:31]3[C:35](=[CH:36][CH:37]=2)[C:34]([CH3:39])([CH3:38])[CH2:33][C:32]3([CH3:41])[CH3:40])O1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:37]3[CH:36]=[C:35]4[C:31](=[CH:30][CH:29]=3)[C:32]([CH3:41])([CH3:40])[CH2:33][C:34]4([CH3:39])[CH3:38])[N:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]Participants
3
Procedure
The preparation is carried out analogously to FS 102 starting from 4-(6-bromopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (US 2005/176722) and 4,4,5,5-tetramethyl-2-(1,1,3,3-tetramethylindan-5-yl)-1,3,2-dioxaborolane.
Sources & evidence
- ORD record
- ord-c536cb5c0d874c23b4842326849f5a9d
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09062015B2
Reaction notes
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