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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2175072Generated: October 31, 2026

2-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 4-[4-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,5-triazin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/2175072

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 53250114—
Reactant845617-09-6HCID 86600711—
Product4-[4-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,5-triazin-2-yl]-piperazine-1-carboxylic acid tert-butyl esterHCID 67254999—

Reaction Steps

The preparation is carried out analogously to FS 102 starting from 4-(4-chloro-1,3,5-triazin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (US 2005/59668) and 2-(8,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09062015B2
Source datasetuspto-grants-2015_06
ORD IDord-9ab575ca3ef642d6b7a2e823b85f0d79
Source noteuspto-grants-2015_06