Potassium Carbonate → HCID 67248303, compound

Participants

Reaction Conditions

Reaction Steps

100 mg (0.29 mmol) of 1-[6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]piperazine are dissolved in 2 ml of DMF, and 47 mg (0.29 mmol) of potassium carbonate are added. 42 μl (0.29 mmol) of 4-bromobutyl acetate are subsequently added, and the mixture is stirred at 50° C. for 24 h. A further 11 μl (0.07 mmol) of 4-bromobutyl acetate are subsequently added, and the mixture is stirred at 50° C. for a further 48 h. The reaction mixture is evaporated, water is added to the residue, the mixture is rendered basic using 1 N NaOH and extracted three times with ethyl acetate. The organic phase is dried over Na2SO4 and evaporated. The crude product is purified by means of column chromatography on silica gel.

Provenance & Evidence