Water → HCID 67249157, compound

Participants

Reaction Steps

50 mg (0.12 mmol) of 7-{6-[4-(5-hydroxypentyl)piperazin-1-yl]pyridin-2-yl}-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one are dissolved in 0.5 ml of THF and 1 ml of methanol, cooled to 0° C., and 4.5 mg (0.12 mmol) of sodium borohydride are added. The reaction mixture is stirred for 30 min, water is added, and the mixture is extracted with ethyl acetate, dried and evaporated. The crude product is purified by means of prep HPLC and subsequently converted into the hydrochloride using methanolic HCl.

Provenance & Evidence