Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 53251220 | HCID 53251220 | — |
| Catalyst | Titanium isopropoxide | HCID 11026 | — |
| Solvent | Dimethylamine | HCID 674 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67249963 | HCID 67249963 | — |
Reaction Steps
50 mg (0.12 mmol) of 7-{6-[4-(5-hydroxypentyl)piperazin-1-yl]pyridin-2-yl}-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one are dissolved in 2 ml of 2M dimethylamine in THF, and 15 mg of sodium cyanoborohydride and 38 mg of titanium(IV) isopropoxide are added, and the mixture is stirred in a pressure vessel at 80° C. Water added to the reaction mixture, sodium hydrogencarbonate solution added, and the mixture extracted with ethyl acetate, dried and evaporated. The crude product is purified by means of prep HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09062015B2 |
|---|
| Source dataset | uspto-grants-2015_06 |
|---|
| ORD ID | ord-c46b97830d3e41e7abb5c50fee9c529b |
|---|
| Source note | uspto-grants-2015_06 |
|---|
