Sodium Hydroxide → HCID 67256203, compound

HRID 2175097Notes

Reaction equation

HRID 2175097 reaction equation
[OH-].[Na+].[CH3:3][C:4]1([CH3:36])[CH2:13][CH2:12][C:11]([CH3:15])([CH3:14])[C:10]2[CH:9]=[C:8]([C:16]3[N:21]=[C:20]([N:22]4[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][N:30]5[CH2:34][CH2:33][O:32]C5=O)[CH2:24][CH2:23]4)[CH:19]=[CH:18][CH:17]=3)[CH:7]=[CH:6][C:5]1=2>CO>[CH3:3][C:4]1([CH3:36])[CH2:13][CH2:12][C:11]([CH3:14])([CH3:15])[C:10]2[CH:9]=[C:8]([C:16]3[N:21]=[C:20]([N:22]4[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][NH:30][CH2:34][CH2:33][OH:32])[CH2:24][CH2:23]4)[CH:19]=[CH:18][CH:17]=3)[CH:7]=[CH:6][C:5]1=2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67247042HCID 67247042, compound

Product 1

HCID 67256203HCID 67256203, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

450 μl of 1 N NaOH were added to 70 mg (0.15 mmol) of 3-(2-{4-[6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]piperazin-1-yl}ethyl)oxazolidin-2-one in 2 ml of methanol, and the mixture was refluxed for 3 days. The reaction mixture was evaporated, extracted with ethyl acetate, dried and evaporated. The crude product was purified by means of pep. HPLC.

Workup

  1. temperaturethe mixture was refluxed for 3 days
  2. customThe reaction mixture was evaporated
  3. extractionextracted with ethyl acetate
  4. customdried
  5. customevaporated
  6. customThe crude product was purified by means of pep

Sources & evidence

ORD record
ord-52fc76178ad1414eb740436ca3203075
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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