HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3aR,4S,7aS)-2,2-dimethylhexahydrobenzo-1,3-dioxol-4-ylamine → ((3aR,4S,7aS)-2,2-Dimethylhexahydrobenzo-1,3-dioxol-4-yl)-[6'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,4,5,6-tetrahydro-2H-1,2'-bipyridinyl-4-yl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3aR,4S,7aS)-2,2-dimethylhexahydrobenzo-1,3-dioxol-4-ylamine | HCID 67248314 | — |
| Reactant | 6'-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2,3,5,6-tetrahydro-1,2'-bipyridinyl-4-one | HCID 67248401 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | ((3aR,4S,7aS)-2,2-Dimethylhexahydrobenzo-1,3-dioxol-4-yl)-[6'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,4,5,6-tetrahydro-2H-1,2'-bipyridinyl-4-yl]amine | HCID 67248776 | — |
Reaction Steps
The preparation is carried out analogously to FS1008 in THF starting from 62 mg (0.360 mmol) of (3aR,4S,7aS)-2,2-dimethylhexahydrobenzo-1,3-dioxol-4-ylamine and 145 mg (0.360 mmol) of 6′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2,3,5,6-tetrahydro-1,2′-bipyridinyl-4-one. The purification is carried out by means of flash chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062015B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-d4c10d4f62d645b88ec2471e5e38b6df |
| Source note | uspto-grants-2015_06 |