Ethanolamine → HCID 77231000, compound

HRID 2175113Notes

Reaction equation

HRID 2175113 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][CH2:16][CH2:17]CCO)[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.C(CN)[OH:22]>>[Br:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][CH2:16][CH2:17][OH:22])[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 77231001HCID 77231001, compound

Product 1

HCID 77231000HCID 77231000, compound

Procedure

The preparation is carried out analogously to 4-[1-(6-bromopyridin-2-yl)azepan-4-ylamino]butan-1-ol starting from 99 μl (1.65 mmol) of ethanolamine 85 mg, colourless oil, Rt.=1.55 min (method B), LCMS: 315 (M+H).

Workup

  1. custom=1.55 min (method B), LCMS

Sources & evidence

ORD record
ord-e86824a266174351bc70f19e640a72ce
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

Loading…