Hydrochloric Acid → HCID 71536097, compound

Participants

Reaction Steps

To a solution of (49.1) (48.5 mg, 0.085 mmol) in MeOH (2 mL) was added HCl solution in MeOH (1M) (5 mL, 5.00 mmol). The reaction mixture was stirred at rt for 1 h, quenched with saturated NaHCO3 solution and extracted with extracted with CH2Cl2. The combined organic layers were dried over anhydrous Na2SO4, concentrated, purified via biotage by flash chromatography on silica gel using a gradient of 0-10% MeOH/CH2Cl2 to give the title compound (38 mg, 0.083 mmol, 98% yield). [Method 1E]

Provenance & Evidence