Tetrabutylammonium Fluoride → HCID 86696263, compound

Participants

Reaction Steps

To a solution of (53.1) (100 mg, 0.188 mmol) in THF (10 ml), TBAF (98 mg, 0.376 mmol) was added. The reaction mixture was stirred at rt for 3 h. The solvent was then removed under reduced pressure. The residue was dissolved in 30 ml of DCM, washed with water (10 ml×3) and brine (10 ml) successively. The organic phase was dried over Na2SO4, then filtered and concentrated. The residue was purified by silica gel chromatography (DCM/MeOH=10/1) to afford the title compound as pale yellow solid (22 mg, 28% yield). [Method 3]

Provenance & Evidence