Hydrochloric Acid → HCID 71536919, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (77.3) (10 mg, 0.025 mmol) and hydroxylamine hydrochloride (6.86 mg, 0.099 mmol) in EtOH (5 ml) was added 0.01 ml of HCl (2 N) and the mixture was stirred in a sealed tube at 80° C. overnight. The mixture was evaporated to dryness and dissolved in H2O again, which was neutralized immediately by NaHCO3 until pH reached about 9. The resulted precipitate was filtered quickly. The precipitate was dissolved in DCM/MeOH (10/1) and washed again by water. The organic phase was dried over Na2SO4, filtered and evaporated to give the title compound (6.8 mg, yield 60.1%).

Provenance & Evidence