Nitrogen → HCID 86696283, compound

Participants

Reaction Conditions

Reaction Steps

The solution of (81.1) (256.5 mg, 0.546 mmol) and PdCl2(PPh3)2 (38.4 mg, 0.055 mmol) in DMF (10 ml) was bubbled by N2 for 5 min. Tributyl(1-ethoxyvinyl)stannane (296 mg, 0.820 mmol) was added. The reaction tube was flushed by N2 for 5 min again and sealed. The sealed-tube was stirred at 85° C. for 16 h. The mixture was evaporated to dryness and the residue was purified by flash chromatography (CombiFlash, ISCO, eluent MeOH/DCM from 0 to 10%) to afford the title compound (35 mg, yield 13.91%). LCMS (method A): [M+H]+=461.2, tR=1.96 min.

Provenance & Evidence