HCID 58497414, compound → HCID 58497453, compound

HRID 2175188Notes

Reaction equation

HRID 2175188 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:9][NH:10][C:11]1[C:16]([N+:17]([O-])=O)=[CH:15][CH:14]=[CH:13][N:12]=1)[CH2:6][CH2:7][CH3:8])[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:9][NH:10][C:11]1[C:16]([NH2:17])=[CH:15][CH:14]=[CH:13][N:12]=1)[CH2:6][CH2:7][CH3:8])[CH3:2]

Participants

4

Reactant 1

HCID 58497414HCID 58497414, compound

Product 1

HCID 58497453HCID 58497453, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 2-[(3-nitro-pyridin-2-ylamino)-methyl]-pentanoic acid ethyl ester (90 mg, 0.32 mmol) in EtOH (5 mL) was added Pd/C (20 mg). The reaction mixture was de-gassed using house vacuum and saturated with H2. The reaction mixture was stirred at room temperature for 18 hours. The mixture was filtered through a pad of celite and the filtrate was concentrated to afford 70 mg (87%) of the desired product which was used for the next reaction without further purification.

Workup

  1. customThe reaction mixture was de-gassed
  2. filtrationThe mixture was filtered through a pad of celite
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-cbc2f09923b74edda0f0924a294b82cd
Source dataset
uspto-grants-2015_06
Patent number
US09062056B2

Reaction notes

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