Acetic Acid → HCID 58497435, compound

Participants

Reaction Steps

To a stirred solution of (R)-3-[5-cyano-2-oxo-1-(1,4,6-trimethyl-1H-indol-3-ylmethyl)-1,2-dihydro-imidazo[4,5-b]pyridin-3-yl]-3-(4-fluoro-phenyl)-propionic acid methyl ester (0.17 g, 0.33 mmol) in dioxane (10 ml) and water (3 ml) was added lithium hydroxide monohydrate (70 mg, 1.66 mmol). The reaction was stirred for 24 hours after which time it was diluted with water and acidified using acetic acid. The resulting precipitate was collected via filtration and washed with water. The remaining solid was purified via preparative TLC (2×1 mm silica gel plates, 5% MeOH/Dichloromethane) to afford 22 mg (13%) of the title compound. LCMS, M++1, m/z: 516.20.

Provenance & Evidence