HRID2175260

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14523558

1,1-Dimethylethyl N-[3-(bromomethyl)phenyl]carbamate

C12H16BrNO2

结构：Cc1cccc(OCCCC(=O)N2CCCc3c(-c4cnn(Cc5cccc(N)c5)c4)cccc32)c1C

HCID86712585

未命名化合物

HCID86712586

未命名化合物

PRODUCTS

生成物

结构：Cc1cccc(OCCCC(=O)N2CCCc3c(-c4cnn(C(C)c5cccc(N)c5)c4)cccc32)c1C

HCID86712587

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using a procedure analogous to 1-(5-(1-(3-aminobenzyl)-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-4-(2,3-dimethylphenoxy)butan-1-one except that tert-butyl 3-(bromomethyl)phenylcarbamate was replaced with tert-butyl 3-(1-bromoethyl)phenylcarbamate. LCMS, [M+H]+=509.5.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6de6a5d602fa405388305c873c898a3a
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09062028B2
来源说明: uspto-grants-2015_06

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([CH:35]=[CH:36][CH:37]=1)[CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:12]=2[CH2:13][CH2:14][CH2:15][N:16]3[C:21](=[O:34])[CH2:22][CH2:23][CH2:24][O:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:27]=2[CH3:33])[CH:8]=[N:7]1.Br[CH2:39]C1C=C(NC(=O)OC(C)(C)C)C=CC=1.BrC(C1C=C(NC(=O)OC(C)(C)C)C=CC=1)C>>[NH2:1][C:2]1[CH:3]=[C:4]([CH:5]([N:6]2[CH:10]=[C:9]([C:11]3[CH:20]=[CH:19][CH:18]=[C:17]4[C:12]=3[CH2:13][CH2:14][CH2:15][N:16]4[C:21](=[O:34])[CH2:22][CH2:23][CH2:24][O:25][C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:27]=3[CH3:33])[CH:8]=[N:7]2)[CH3:39])[CH:35]=[CH:36][CH:37]=1