monoMethyl succinate → Methyl 4-(5-bromo-3,4-dihydroquinolin-1(2H)-yl)-4-oxobutanoate

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Reaction Steps

The title compound was prepared using a procedure analogous to 1-(5-bromo-3,4-dihydroquinolin-1(2H)-yl)-4-(2,3-dimethylphenoxy)butan-1-one except that 4-(2,3-dimethylphenoxy)butanoic acid was replaced by 4-methoxy-4-oxobutanoic acid. LCMS, [M+Na]+=349.9. 1H NMR (400 MHz, CDCl3) δ 7.38 (d, J=8.0 Hz, 1H), 7.25 (br. s, 1H), 7.03 (t, J=8.1 Hz, 1H), 3.80-3.73 (m, 2H), 3.68 (d, J=11.0 Hz, 2H), 3.66 (s, 3H), 2.81 (t, J=6.9 Hz, 2H), 2.78-2.72 (m, 2H), 2.71-2.63 (m, 2H), 1.99 (dd, J=12.5, 6.6 Hz, 2H).

Provenance & Evidence