HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Cresol → tert-Butyl 3-((3-(1-(4-(o-tolyloxy)butanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)benzyloxy)carbonylamino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Cresol | HCID 335 | — |
| Reactant | 2,4,5-Trichlorophenol | HCID 7271 | — |
| Reactant | tert-Butyl 3-((3-(1-(4-hydroxybutanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)benzyloxy)carbonylamino)propanoate | HCID 70982571 | — |
| Reactant | Ethyl 2-(4-(1-(4-(2,4,5-trichlorophenoxy)butanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)-1H-pyrazol-1-yl)acetate | HCID 70982627 | — |
| Reactant | Ethyl 2-(4-(1-(4-hydroxybutanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)-1H-pyrazol-1-yl)acetate | HCID 70983434 | — |
| Product | tert-Butyl 3-((3-(1-(4-(o-tolyloxy)butanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)benzyloxy)carbonylamino)propanoate | HCID 70982731 | — |
Reaction Steps
The title compound was prepared using a procedure analogous to ethyl 2-(4-(1-(4-(2,4,5-trichlorophenoxy)butanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)-1H-pyrazol-1-yl)acetate except that ethyl 2-(4-(1-(4-hydroxybutanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)-1H-pyrazol-1-yl)acetate was replaced with tert-butyl 3-((3-(1-(4-hydroxybutanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)benzyloxy)carbonylamino)propanoate and 2,4,5-trichlorophenol was replaced with o-cresol. LCMS, [M+H]+=587.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062028B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-4132530ba8f64a50819f9d8a30e02f30 |
| Source note | uspto-grants-2015_06 |