Diethyl Ether → HCID 58565353, compound

Participants

Reaction Steps

To a mixture of 6-chloro-1-(3-fluorophenyl)-1H-indole-2-carbaldehyde (50 mg, 0.18 mmol) in tetrahydrofuran (5 mL) was added 3.0 M methylmagnesium bromide in ether (0.091 mL, 0.27 mmol). The reaction was stirred at room temperature for 1 hour, quenched with water, and then extracted with ethyl acetate (EtOAc). The combined organic layers were washed with brine, dried over MgSO4 and concentrated to give the desired product (51 mg). The crude product was used directly in next step. LCMS calculated for C16H14ClFNO(M+H)+: m/z=290.1. Found: 289.7.

Provenance & Evidence