Trimethylphosphine → HCID 58565355, compound

Participants

Reaction Steps

To a solution of 2-(1-azidoethyl)-6-chloro-1-(3-fluorophenyl)-1H-indole (55 mg, 0.17 mmol) in tetrahydrofuran (2 mL) was added 1.00 M of trimethylphosphine in tetrahydrofuran (0.26 mL, 0.26 mmol) and the resultant mixture was stirred at room temperature for 1 hour. The mixture was concentrated to give the desired amine (50 mg). The crude product was used directly in the next step. LCMS calculated for C16H12ClFN(M-NH2)+: m/z=272.1. Found: 272.0.

Provenance & Evidence