HCID 58565354, compound → HCID 58565352, compound

Participants

Reaction Steps

To a mixture of 4-chloro-1-(3-fluorophenyl)-N-methoxy-N-methyl-1H-indole-2-carboxamide (0.44 g, 1.3 mmol) in tetrahydrofuran (10 mL) was added 1.4 M methylmagnesium bromide in tetrahydrofuran (4.7 mL, 6.6 mmol) dropwise. The reaction was stirred at room temperature overnight, then quenched with aqueous saturated NH4Cl solution and extracted with EtOAc. The extracts were dried over MgSO4, concentrated and purified on silica gel (eluting with 0-10% EtOAc in hexane) to give the desired product (0.26 g, 68%). LCMS calculated for C16H12ClFNO(M+H)+: m/z=288.1. Found: 288.0.

Provenance & Evidence