HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → HCID 58565371, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 1H-Indole-2-methanol, 1-(3-fluorophenyl)-α-methyl-, 2-methanesulfonate | HCID 86660480 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58565371 | HCID 58565371 | 49% |
Reaction Steps
To the crude 1-[1-(3-fluorophenyl)-1H-indol-2-yl]ethyl methanesulfonate in N,N-dimethylformamide (5 mL) was added sodium azide (0.20 g, 3.0 mmol). The reaction was stirred at room temperature for 2 hr, quenched with water, and extracted with EtOAc. The combined organic layers were dried over MgSO4, concentrated and purified on silica gel (eluting with 0-30% EtOAc in hexane) to give the desired product (0.14 g, 49%). LCMS calculated for C16H13FN(M-N3)+: m/z=238.1. Found: 238.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062055B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-31a891857b264d4eae5d883f77deb276 |
| Source note | uspto-grants-2015_06 |