Chlorosuccinimide → HCID 58565370, compound

Participants

Reaction Steps

A solution of N-chlorosuccinimide (0.015 g, 0.11 mmol) in DMF (0.1 mL) was added dropwise to an ice-cooled solution of tert-butyl {1-[1-(3-fluorophenyl)-1H-indol-2-yl]ethyl}carbamate (35 mg, 0.099 mmol) in N,N-dimethylformamide (0.5 mL, 6 mmol). The resulting mixture was allowed to warm to room temperature and stirred for an additional 4 hours. The mixture was then diluted with water and then extracted with EtOAc. The combined organic layers were dried over MgSO4, concentrated, and purified on silica gel (eluting with 0-10% EtOAc in hexane) to give the desired product (36 mg, 94%).

Provenance & Evidence