Hydrochloric Acid → HCID 58565340, compound

Participants

Reaction Steps

Hydrogen chloride (4.0 M) in 1,4-dioxane (0.5 mL, 20 mmol) was added to a solution of tert-butyl {1-[3-chloro-1-(3-fluorophenyl)-1H-indol-2-yl]ethyl}carbamate (36 mg, 0.092 mmol) in 1,4-dioxane (1.0 mL) and the reaction was stirred at room temperature for 1 hour. The mixture was diluted with EtOAc, washed with saturated NaHCO3 solution and water. The combined extracts were dried over MgSO4 and concentrated to give the desired product (31.5 mg). LCMS calculated for C16H12ClFN(M-NH2)+: m/z=272.1. Found: 272.0.

Provenance & Evidence